ABSTRACT
INTRODUCCIÓN: El Carcinoma basocelular (CBC) es la neoplasia más frecuente en la población humana. Se ha observado un aumento de su incidencia en todos los países, incluyendo a Chile. CBC es un tumor heterogéneo clínica e histológicamente. Entre sus factores de riesgo, destaca la exposición a la radiación ultravioleta. En Chile, en la última década se han realizado numerosas campañas de prevención del cáncer cutáneo y de detección precoz de esta neoplasia. El propósito de este trabajo es comparar el comportamiento del CBC en relación a parámetros demográficos, clínicos e histológicos en dos periodos de tiempo, 1995-1999 y 2005-2009 en la población de cuatro hospitales públicos de Santiago de Chile...
INTRODUCTION: Basal cell carcinoma (BCC) is the most common malignancy in the human population. There has been an increased incidence in all countries, including Chile. BCC is a clinically and histologically heterogeneous tumor. The main risk factor of BCC is the ultraviolet radiation exposure. In Chile, in the last decade, there have been numerous campaigns of skin cancer prevention and early detection of this neoplasm. The purpose of this paper is to compare the behavior of BCC in relation to demographic, clinical and histological parameters in two periods, 1995-1999 and 2005-2009 in the population of four hospitals in Santiago de Chile
Subject(s)
Humans , Male , Adolescent , Psoriasis/epidemiology , Chile , Sex Factors , Epidemiology, Descriptive , Prevalence , Prospective Studies , Age of Onset , Age and Sex DistributionABSTRACT
Background: Methotrexate is one of the best systemic treatments for psoriasis. However it has significant adverse effects such as myelotoxicity and hepatotoxicity. Aim: To evaluate serum liver test in psoríatic patients treated with methotrexate. Material and Methods: Retrospective review of medical records of psoríatic patients treated with methotrexate between the years 2000 and 2005. All patients received a minimum of 7.5 mg weekly of methotrexate, for at íeast 4 weeks. Results: Sixty three patients were included. Mean cumulative dose of methotrexate was 576 mg. Thirty two percent had alterations in liver tests, but only 9 percent had values that duplicated the upper limit of normal range of aminotransferases or alkaline phosphatases or a serum bilirubin over 2 mg/dl. We did not find a direct relationship between the dose of methotrexate and the magnitude of liver test alterations. Only one patient exceeded 1.5 g as cumulative dose. A liver biopsy performed to him, did not show signs of fibrosis. Conclusions: This retrospective study does not show a direct relationship between weekly doses, cumulated dose and length of treatment with methotrexate, and the degree of alteration of serum liver tests.
Subject(s)
Female , Humans , Male , Chemical and Drug Induced Liver Injury , Dermatologic Agents/adverse effects , Liver/drug effects , Methotrexate/adverse effects , Psoriasis/drug therapy , Chemical and Drug Induced Liver Injury , Chemical and Drug Induced Liver Injury, Chronic , Acute Disease , Biomarkers/blood , Dermatologic Agents/administration & dosage , Liver Cirrhosis/chemically induced , Liver Cirrhosis/pathology , Liver Function Tests , Liver/pathology , Methotrexate/administration & dosage , Psoriasis/pathology , Retrospective Studies , Transaminases/bloodABSTRACT
Traumatic injuries of the diaphragm are a known consequence of severe trauma, usually of the blunt type. Its incidence is increasing due to the rise in number and severity of accidents, especially car accidents. Diagnosing a traumatic diaphragmatic rupture is still a challenge for both radiologists and surgeons, with a delayed diagnosis in more than half of cases, with the consequent development of latent hernia. This hernia may manifest with symptoms varying from unspecific to bowel strangulation. We present the case of a patient with colonic obstruction secondary to a traumatic diaphragmatic hernia, with previous history of a penetrating thoracoabdominal trauma seven years before. Radiologic methods and signs for the diagnosis of this pathology are reviewed.
Resumen: Las lesiones traumáticas del diafragma son consecuencia conocida de un trauma grave, gene-ralmente de tipo contuso. Su incidencia ha aumentado debido al crecimiento en número y severidad de los accidentes, en especial del tránsito. Su diagnóstico continúa siendo un desafío para cirujanos y radiólogos, diagnosticándose tardíamente hasta en más de la mitad de los casos, dejando una hernia diafragmática latente, que puede manifestarse con síntomas que varían desde inespecíficos hasta la estrangulación de un asa intestinal. Se presenta el caso de un paciente con obstrucción intestinal de colon secundaria a una hernia diafragmática traumática atascada, con historia de un traumatismo penetrante toracoabdominal ocurrido siete años antes. Se revisan los métodos y signos radiológicos de mayor utilidad para el diagnóstico de esta patología.